ICD-11 classes
13 Diseases of the digestive system
Diseases of liver
Neoplasms of the liver
2C12 — Malignant neoplasms of liver or intrahepatic bile ducts

ICD-11 2C12 — Malignant neoplasms of liver or intrahepatic bile ducts

The most frequent and important hepatic neoplasm is the primary hepatocellular carcinoma (HCC). In many parts of the world, in particular Africa and Asia, it poses a significant disease burden. In these high incidence regions, chronic infection with hepatitis B virus (HBV) is the principal underlying cause, with the exception of Japan which has a high prevalence of hepatitis C infection. HBV vaccination has become a powerful tool in reducing cirrhosis and HCC, but implementation is still suboptimal in several high risk regions. In Western countries, chronic alcohol abuse is a major aetiological factor. Hepatic cholangiocarcinoma has a different geographical distribution, with peak incidences in Northern Thailand. Here, it is caused by chronic infection with the liver fluke, Opisthorchis Viverrini, which is ingested through infected raw fish.

The diagnosis includes nothing.

Diagnosis with code 2C12 contains 3 clarifying diagnoses:

1. 2C12.0 — Malignant neoplasm of liver
   It contains 5 clarifying diagnoses.
2. 2C12.1 — Malignant neoplasm of intrahepatic bile ducts
   It contains 2 clarifying diagnoses.
3. 2C12.Z — Malignant neoplasms of liver or intrahepatic bile ducts, unspecified

The diagnosis is coded elsewhere:

• Malignant neoplasms of digestive organs #1956
• Malignant neoplasms of liver or intrahepatic bile ducts #2059