ICD-11 classes
14 Diseases of the skin
Skin disorders involving certain specific body regions
Skin disorders involving the head and neck
Dermatoses of the lips or oral cavity
DA01 — Disorders of oral mucosa
DA01.1 — Noninfectious erosive or ulcerative disorders of oral mucosa
DA01.12 — Chronic ulcerative stomatitis
ICD-11 DA01.12 — Chronic ulcerative stomatitis
Chronic ulcerative stomatitis (CUS) is a rare disease which presents with chronic oral mucosal erosions and ulceration resembling erosive lichen planus but refractory to standard therapies. It typically occurs in older women. Diagnosis requires the demonstration of speckled granular perinuclear IgG deposits in the basal and parabasal layers of oral epithelium (stratified epithelium-specific antinuclear or SES-ANA pattern). There is increasing evidence that CUS is an autoimmune disease provoked by circulating IgG antibodies directed against delta-Np63, an isoform of the p53 family of nuclear transcription factors which is present around the nuclei of normal oral epithelial basal keratinocytes. CUS normally responds to treatment with hydroxychloroquine.
The diagnosis includes nothing.
The diagnosis excludes nothing.
It has no clarifying diagnoses.
The diagnosis is coded elsewhere: