ICD-11 classes
05 Endocrine, nutritional or metabolic diseases
Endocrine diseases
Disorders of the pituitary hormone system
5A60 — Hyperfunction of pituitary gland
5A60.2 — Syndrome of inappropriate secretion of antidiuretic hormone
ICD-11 5A60.2 — Syndrome of inappropriate secretion of antidiuretic hormone
Syndrome of inappropriate antidiuretic hormone (ADH) secretion (SIADH) is characterised by continued ADH secretion, leading to hyponatremia, hypoosmolality and natriuresis. Exact prevalence is unknown. The disease has been described in all age groups. SIADH is often associated with tumours, pulmonary disease, central nervous system disorders or exposure to drugs. Occasionally, it is found in patients with adrenal, thyroid or pituitary insufficiency. The disorder is caused by gain-of-function mutations in the gene encoding the vasopressin V2 receptor. Fluid restriction is the most common treatment. The outcome is related to the underlying and associated disorders.
The diagnosis includes nothing.
The diagnosis excludes nothing.
Diagnosis with code 5A60.2 contains 3 clarifying diagnoses: