ICD-11 classes
05 Endocrine, nutritional or metabolic diseases
Nutritional disorders
Nutritional or toxic disorders of the nervous system
8D43 — Neurological disorders due to toxicity
8D43.2 — Neuropathy due to toxicity

ICD-11 8D43.2 — Neuropathy due to toxicity

In considering the diagnosis of toxic neuropathy, two criteria should be met: (1) Exposure can be verified and temporally related to the onset of clinical symptoms. Neuropathic symptoms usually occur concurrently with the exposure or following a variable latency of up to several months. (2) There must be neurological signs and abnormal electrodiagnostic studies, because many toxic neuropathies are subclinical, subjective symptoms may or may not occur. Removal from exposure results in cessation of progression of symptoms and the deficit. Most toxins produce symmetrical axonal degeneration in a length-dependent pattern, beginning in the distal segments of the long and large-calibre nerve fibres eventually spreading proximally with continued exposure. In addition to motor and /or sensory deficits, severe pain may be a characteristic feature.

The diagnosis includes nothing.

The diagnosis excludes nothing.

Diagnosis with code 8D43.2 contains 5 clarifying diagnoses:

1. 8D43.20 — Drug-induced polyneuropathy
2. 8D43.21 — Post radiation polyneuropathy
3. 8D44.0 — Alcoholic polyneuropathy
4. 8D43.2Y — Other specified neuropathy due to toxicity
5. 8D43.2Z — Neuropathy due to toxicity, unspecified

The diagnosis is coded elsewhere:

• Neurological disorders due to toxicity #7572
• Neuropathy due to toxicity #7579