ICD-11 classes
08 Diseases of the nervous system
Multiple sclerosis or other white matter disorders
8A45 — Secondary white matter disorders
8A45.3 — White matter disorders due to nutritional deficiency
8A45.30 — White matter disorder due to vitamin B12 deficiency
ICD-11 8A45.30 — White matter disorder due to vitamin B12 deficiency
Neurological features occur in 40% of patients with B12 deficiency. Subacute combined degeneration is a potentially reversible neurological complication of a vitamin B12 deficiency. Symptoms develop insidiously and neuropathic manifestations include progressive paraesthesia distally, numbness, gait ataxia and diminished proprioception in the lower limbs, while the myelopathic component leads to variable motor impairment due to pyramidal tract dysfunction. Incontinence of bowel and bladder with impotence and postural hypotension occur as part of the myelopathy. Central manifestations include confusion, depression, progressive hallucination and mental slowing. There may also be optic neuropathy present.
The diagnosis includes nothing.
The diagnosis excludes nothing.
It has no clarifying diagnoses.
The diagnosis is coded elsewhere: