ICD-11 classes
08 Diseases of the nervous system
Multiple sclerosis or other white matter disorders
8A45 — Secondary white matter disorders
8A45.4 — White matter disorders due to certain specified systemic...
8A45.45 — Demyelination due to mitochondrial disease

ICD-11 8A45.45 — Demyelination due to mitochondrial disease

Mitochondrial disorders can cause multifocal and relapsing central nervous system syndromes. Mitochondrial disorders which can cause such syndromes include Mitochondrial Encephalopathy with Lactic Acidosis and Stroke (MELAS), and Leigh's disease. MELAS is a progressive neurodegenerative disorder associated with headache, treatment resistant partial seizures, short stature, muscle weakness, exercise intolerance, deafness, diabetes, and slow progressive dementia. Leigh syndrome or subacute necrotizing encephalomyelopathy is the prototype mitochondrial disease, with hallmark neuroimaging findings.

The diagnosis includes nothing.

The diagnosis excludes nothing.

It has no clarifying diagnoses.