ICD-11 classes
08 Diseases of the nervous system
Motor neuron diseases or related disorders
8B60 — Motor neuron disease
8B60.0 — Amyotrophic lateral sclerosis

ICD-11 8B60.0 — Amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disorder in which progressive signs of LMN and UMN degeneration are seen within one or more of the four regions: bulbar, cervical, thoracic and lumbosacral. Electrophysiological studies may be required to confirm lower motor neuron degeneration and to exclude alternative causes. Neuroimaging may be performed to exclude other causes, which might explain the clinical and electrophysiological features. Familial ALS (FALS) of autosomal dominant inheritance, constitutes 5 to 10% of ALS. The clinical profile of FALS and sporadic ALS is similar. Mutations in the C9ORF72 and Cu/Zn superoxide dismutase (SOD1) genes constitute 50-60% of FALS.

The diagnosis includes nothing.

The diagnosis excludes nothing.

It has no clarifying diagnoses.