ICD-11 classes
03 Diseases of the blood or blood-forming organs
Neoplasms of haematopoietic or lymphoid tissues
2B30 — Hodgkin lymphoma
2B30.1 — Classical Hodgkin lymphoma

ICD-11 2B30.1 — Classical Hodgkin lymphoma

Classical Hodgkin lymphoma is a B-cell lymphoma characterised histologically by the presence of large mononuclear Hodgkin cells and multinucleated Reed-Sternberg (HRS) cells.A monoclonal B-cell lymphoproliferation in the vast majority of cases. It is characterised by a bimodal age distribution (15-30 years of life and late life) and is often associated with EBV infection. In less than 5% of cases it is a monoclonal proliferation of T-lymphocytes. Morphologically, it is characterised by the presence of Reed-Sternberg cells and mononuclear Hodgkin cells. The Reed-Sternberg and mononuclear Hodgkin cells are CD30 positive in nearly all cases and CD15 positive in the majority of cases.

The diagnosis excludes nothing.

Diagnosis with code 2B30.1 contains 5 clarifying diagnoses:

1. 2B30.10 — Nodular sclerosis classical Hodgkin lymphoma
2. 2B30.11 — Lymphocyte-rich classical Hodgkin lymphoma
3. 2B30.12 — Mixed cellularity classical Hodgkin lymphoma
4. 2B30.13 — Lymphocyte depleted classical Hodgkin lymphoma
5. 2B30.1Z — Classical Hodgkin lymphoma, unspecified

The diagnosis is coded elsewhere:

• Hodgkin lymphoma #1730
• Classical Hodgkin lymphoma #1732